In the post-genomic era, many gene families have been identified. These genes can have overlapping and independent functions. The existence of redundant functions in gene families has made diseases like cancer challenging to treat and cure. The focus of The Flores Laboratory is to understand the intricacy of the p53 family of genes, p53, p63, and p73, in cancer using mouse genetics and biochemical approaches. The goal of our work is to gain a global understanding of the complex functions of this gene family in cancer and to facilitate the design of targeted therapies for cancer patients with alterations in this family of genes. This type of research can be applied to other families of genes with redundant and unique functions in an effort to make significant progress in curing diseases like cancer.