Peer Reviewied Articles
  1. Adelmann C.H., Truong K.A., Saporito R., Du L., Nicholas C., Napoli M., South A., Flores E.F. and Tsai K.Y. MEK is a therapeutic and chemopreventative target in squamous cell carcinoma.
    The Journal of Investigative Dermatology. In press
  2. Napoli M, Venkatanarayan A., Raulji P., Meyers B.A., Norton W., Mangala L.S., Sood A.K., Rodriguez-Aguayo C., Lopez-Berestein G., Vin H., Duvic M., Tetzlaff M.B., Curry J.L., Rook A.H., Abbas H.A., Coarfa C., Gunaratne P.H., Tsai K.Y. and Flores E.R ∆Np63/DGCR8-dependent microRNAs mediate therapeutic efficacy of HDAC inhibitors in cancer.
    Cancer Cell. 2016 Jun 13. Doi:10.1016/j.ccell.2016.04.016
  3. Wang Y, Wang X, Flores ER, Yu J, Chang S. Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation
    Aging Cell. 2016 Apr 26. doi: 10.1111/acel.12476. [Epub ahead of print]
  4. Venkatanarayan A, Raulji P, Norton W, Flores ER Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73.
    Cell Cycle. 2016;15(2):164-71. doi: 10.1080/15384101.2015.1121333.
  5. Wu Y, Lindblad JL, Garnett J, Kamber Kaya HE, Xu D, Zhao Y, Flores ER, Hardy J, Bergmann A Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila.
    Cell Death Differ. 2016 Apr;23(4):723-32. doi: 10.1038/cdd.2015.144. Epub 2015 Nov 6.
  6. Singh MM, Johnson B, Venkatarayan A, Flores ER, Zhang J, Su X, Barton M, Lang F, Chandra J. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma
    Neuro Oncol. 2015 Nov;17(11):1463-73. doi: 10.1093/neuonc/nov041. Epub 2015 Mar 19
  7. Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han HD, Zhang D, Venkatanarayan A, Krohn M, Kristensen VN, Gagea M, Ram P, Liu W, Lopez-Berestein G, Lorenzi PL, Børresen-Dale AL, Chin K, Gray J, Dusetti NJ, McGuire SE, Flores ER, Sood AK, Mills GB Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.
    Cancer Cell. 2014 Dec 8;26(6):863-79. doi: 10.1016/j.ccell.2014.10.010.
  8. Venkatanarayan A, Raulji P, Norton W, Chakravarti D, Coarfa C, Su X, Sandur SK, Ramirez MS, Lee J, Kingsley CV, Sananikone EF, Rajapakshe K, Naff K, Parker-Thornburg J, Bankson JA, Tsai KY, Gunaratne PH, Flores ER. IAPP driven metabolic reprogramming induces regression of p53-deficient tumors in vivo
    Nature. 2014 Nov 17. Doi 10.1038/nature13910 [Epub ahead of print]
  9. Chakravarti D, Su X, Cho MS, Bui NH, Coarfa C, Venkatanarayan A, Benham AL, Flores González RE, Alana J, Xiao W, Leung ML, Vin H, Chan IL, Aquino A, Müller N, Wang H, Cooney AJ, Parker-Thornburg J, Tsai KY, Gunaratne PH, Flores ER. Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8
    Proc Natl Acad Sci USA. 2014 Feb 4; 111 (5): E572-81. Doi:10.1073/pnas. 1319743111. Epub 2014 Jan 21.
  10. Vin H, Ojeda SS, Ching G, Leung ML, Chitsazzadeh V, Dwyer DW, Adelmann CH, Restrepo M, Richards KN, Stewart LR, Du L, Ferguson SB, Chakravarti D, Ehrenreiter K, Baccarini M, Ruggieri R, Curry JL, Kim KB, Ciurea AM, Duvic M, Prieto VG, Ullrich SE, Dalby KN, Flores ER, Tsai KY. BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.
    ELife. 2013 Nov 5;2:e00969. Doi: 10.7554/eLife.00969
  11. Cancino GI, Yiu AP, Fatt MP, Dugani CB, Flores ER, Frankland PW, Josselyn SA, Miller FD, Kaplan DR. Functions of TAp63 and p53 in restraining the development of metastatic cancer
    J Neurosco. 2013 Jul 31;33(31): 12569-85. Doi: 10.1523/JNEUROSCI. 1251-13.2013
  12. Tan EH, Morton JP, Timpson P Tucci P, Melico G, Flores ER, Sansom OJ, Voudsen KH, Muller PA. Functions of TAp63 and p53 in restraining the development of metastatic cancer
    Oncogene. 2013 Jul22 [Epub ahead of print]
  13. Eno CO, Zhao G, Venkatanarayan A, Wang B, Flores ER, Li C. Noxa couples lysosomal membrane permeabilization and apoptosis during oxidative stress.
    Free Radic Biol Med. 2013 Jun 14;65C:26-37
  14. Chari NS, Romano RA, Koster MI, Jaks V, Roop D, Flores ER, Teglund S, Sinha S, Gruber W, Aberger F, Medeiros LJ, Toftgard R, McDonnell TJ Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis.
    Cell Death Differ. 2013 Aug.20(8):1080-8
  15. Terrinoni A, Serra V, Bruno E, Strasser A, Valente E, Flores ER, van Bokhoven H, Lu X, Knight RA, Melino G.Role of p63 and the Notch pathway in cochlea development and sensorineural deafness
    Proc Natl Acad Sci USA. 2013 Apr 30;(11-(18):7300-5.
  16. Liao JM, Zhang Y, Liao W, Zeng SX, Su X, Flores ER, Lu H. IkB Kinase β (IKK β) Inhibits p53 Isoform ϒ (TAp63 ϒ) Transcriptional activity.
    J Biol Chem. 2013 Jun 21; 288(25):18184-93
  17. Tran MN, Choi W, Wszolek MF, Nayai N, Lee IL, Nitti G, Wen S, Flores ER, Siefker- Radtke A, Czernial B, Dinney C, Barton M, McConkey DJ.The p63 isoform ΔNp63a inhibits epithelial-mesenchymal transition in human bladder cancer cells: Role of miR205
    J Biol Chem. 2012 Dec 13. [Epub ahead of print]
  18. Su X, Gi YJ, Chakravarti D, Chan IL, Zhang A, Xia X, Tsai KY, Flores ER. TAp63 is a master transcriptional regulator of lipid and glucose metabolism.
    Cell Metabolism. 2012 Oct 3: 16(4):511-25.
  19. Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moore KA, Snoeck HW, Ma'ayan A, Schaniel C, Lemischka IR. Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling.
    Cell Stem Cell 11(2):179-94, 8/3/2012. PMID: 22862944.
  20. Ahn YH, Gibbons DL, Chakravarti D, Creighton CJ, Rizvi ZH, Adams HP, Pertsemlidis A, Gregory PA, Wright JA, Goodall GJ, Flores ER, Kurie JM. ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.
    J Clin Invest. e-Pub 8/2012. PMID: 22850877.
  21. Wu H, Abou Zeinab R, Flores ER, Leng RP. Pirh2, a Ubiquitin E3 Ligase, Inhibits p73 Transcriptional Activity by Promoting its Ubiquitination.
    Mol Cancer Res. e-Pub 10/2011. PMID: 21994467.
  22. Mitani Y, Li J, Weber RS, Lippman SL, Flores ER, Caulin C, El-Naggar AK. Expression and regulation of the ΔN and TAp63 isoforms in salivary gland tumorigenesis clinical and experimental findings.
    Am J Pathol 179(1):391-9, 7/2011. e-Pub 5/2011. PMCID: PMC3123859.
  23. Bornstein C, Brosh R, Molchadsky A, Madar S, Kogan-Sakin I, Goldstein I, Chakravarti D, Flores ER, Goldfinger N, Sarig R, Rotter V. SPATA18, a Spermatogenesis-Associated Gene, Is a Novel Transcriptional Target of p53 and p63.
    Mol Cell Biol 31(8):1679-89, 4/2011. e-Pub 2/2011. PMID: 21300779.
  24. Su X, Chakravarti D, Cho MS, Liu L, Gi YJ, Lin YL, Leung ML, El-Naggar A, Creighton CJ, Suraokar MB, Wistuba I, Flores ER. TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs.
    Nature (*Featured in Nature Reviews Cancer, Genome Biology, and Science) 467(7318):986-90, 10/2010. PMID: 20962848.
  25. Cho MS, Chan IL, Flores ER. DeltaNp63 transcriptionally regulates brachyury, a gene with diverse roles in limb development, tumorigenesis and metastasis.
    Cell Cycle (*Commentary in Cell Cycle) 9(12). e-Pub 6/2010. PMID: 20519941.
  26. Lin Y-L, Sengupta S, Gurdziel K, Bell, G, Jacks T, and Flores ER. p63 and p73 transcriptionally regulate genes involved in DNA repair.
    PLoS Genetics 5(10):e1000680, 10/2009. e-Pub 10/2009.
  27. Su X, Cho MS, Gi YJ, Ayanga BA, Sherr CJ, Flores ER. Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf.
    EMBO J 28(13):1904-15, 7/8/2009. e-Pub 6/4/2009. PMCID: PMC2711186.
  28. Su X, Paris M, Gi Y-J, Tsai KY, Cho MS, Lin Y-L, Biernaskie JA, Sinha S, Prives C, Pevny LH, Miller FD, and Flores ER. TAp63 prevents premature aging by promoting adult stem cell maintenance.
    Cell Stem Cell (*Commentary in the same issue of Cell Stem Cell) 5(1):64-75, 7/2009. PMID: 19570515.
  29. Talos F, Nemajerova A, Flores ER, Petrenko O, and Moll U. p73 suppresses polyploidy and aneuploidy in the absence of functional p53.
    Mol Cell 27(4):647-659, 8/2007. PMID: 17707235.
  30. Flores ER, Sengupta S, Miller JB, Newman JJ, Bronson R, Crowley D, Yang A, McKeon F, Jacks T. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family.
    Cancer Cell 7(4):363-73, 4/2005. PMID: 15837625.
  31. Reczek EE, Flores ER, Tsay AS, Attardi LD, Jacks T. Multiple response elements and differential p53 binding control Perp expression during apoptosis.
    Mol Cancer Res 1(14):1048-57, 12/2003. PMID: 14707288.
  32. Flores ER, Tsai KY, Crowley D, Sengupta S, Yang A, McKeon F, Jacks T. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage.
    Nature (*Commentary in Cancer Cell and featured in Nature Reviews) 416(6880):560-4, 4/2002. PMID: 11932750.
  33. de Vries A, Flores ER, Miranda B, Hsieh HM, van Oostrom CT, Sage J, Jacks T. Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function.
    Proc Natl Acad Sci U S A 99(5):2948-53, 3/2002. PMID: 11867759.
  34. Duensing S, Duensing A, Flores ER, Do A, Lambert PF, Munger K. Centrosome abnormalities and genomic instability by episomal expression of human papillomavirus type 16 in raft cultures of human keratinocytes.
    J Virol 75(16):7712-6, 8/2001. PMID: 11462043.
  35. Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W, Flores ER, Tsai KY, Jacks T, Vousden KH, Kaelin WG, Jr. Role for the p53 homologue p73 in E2F-1-induced apoptosis.
    Nature 407(6804):645-8, 10/2000. PMID: 11034215.
  36. Flores ER, Allen-Hoffmann BL, Lee D, Lambert PF. The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle.
    J Virol 74(14):6622-31, 7/2000. PMID: 10864676.
  37. Flores ER, Lambert PF. Evidence for a switch in the mode of human papillomavirus type 16 DNA replication during the viral life cycle.
    J Virol 71(10):7167-79, 10/1997. PMID: 9311789.
Invited Articles
  1. Napoli M and Flores E.R Unifying the p73 knockout phenotypes: TAp73 orchestrates multiciliogenesis. Genes & Development. In press
  2. Botchkarev VA, Flores ER Tp53/p63/p73 in the epidermis in health and disease.
    Cold Spring Harb Perspect Med. 2014 Aug 1;4(8) pii:a015248. Doi: 10.1101/cshperspect.a015248
  3. Napoli M, Flores ER The family that eats together stays together: new p53 family transcriptional targets in autophagy.
    Genes Dev. 2013 May 1;27(9):971-4
  4. Su X, Chakravarti D, Flores ER. p63 steps into the limelight: crucial roles on the
    suppression of tumorigenesis and metastasis
    Nat Rev Cancer. 2012 Dec 21;13(2):136-43.
  5. Flores ER, Lozano G. The p53 family grows old.
    Genes Development. 2012 Sep 15;26(18):1997-2000
  6. Flores ER. p73 is critical for the persistence of memory.
    Cell Death & Differentiation 18(3):381-2, 3/2011.
  7. Flores ER, Halder G. Stem cell proliferation in the skin: alpha-catenin takes over the hippo pathway.
    Sci Signal 4(183):pe34, 2011. e-Pub 7/2011. PMID: 21791701.
  8. Su X and Flores ER. TAp63: The Fountain of Youth. Impact Aging 1(10):866-869,, 10/2009. e-Pub 10/2009.
  9. Flores ER. The roles of p63 in cancer.
    Cell Cycle 6(3). e-Pub 2/2007. PMID: 17264676.
  10. Iwakuma T, Lozano G, Flores ER. Li-Fraumeni syndrome: a p53 family affair.
    Cell Cycle 4(7):865-7, 7/2005. PMID: 15917654.
Book Chapters
  1. Flores ER and Jacks T. p53 Family Members; p63 and p73. In: The p53 Tumor Suppressor Pathway and Cancer, 2005.