Biomaterials in Chimeric Antigen Receptor T-Cell Process Development

ConspectusChimeric antigen receptor (CAR) T-cell therapy has changed the landscape of cancer treatments, utilizing modified ex vivo autologous T cells to treat relapsed or refractory B-cell leukemia and lymphoma. However, the impact of wider therapy has been limited, in part, the production process is complicated, lengthy, and expensive. Thus, as a T-cell therapy CAR more developed to treat other cancers, continuous innovation in manufacturing cell will be crucial to their successful clinical implementation.

This account, we describe our research efforts using biomaterials to raise three fundamental steps in T-cell manufacturing CAR: (1) isolation, (2) activation, and (3) genetic modification.Recognizing T cell isolation reagent clinically and supply costs a high obstacle, we developed a synthetic DNA aptamer and complementary reversal agent technology that CD8 + T cells isolated label-free with high purity and yield of mononuclear cells of peripheral blood. Spirit, CAR T cells are made of both antibody and T cell-isolated aptamer comparable in therapeutic potential.

Invention and design of other T-cell specific aptamers and corresponding reversal reagents can fully realize the potential of this approach, enabling inexpensive isolation of different T cell populations in a single insulating step.Current some material ex vivo T-cell activation does not accurately mimic the in situ activation of cells T by antigen presenting cells (APC). They are not the same cause expansion of CD4 + and CD8 + T cells, so it requires a separate production of CD4 + and CD8 + CAR T cells for therapeutic infusion calls for balanced composition.

 Biomaterials in Chimeric Antigen Receptor T-Cell Process Development
Biomaterials in Chimeric Antigen Receptor T-Cell Process Development

To address this shortcoming, we designed a panel of cell-templated silica microparticles with a biodegradable supported lipid bilayers that display ligand stimulation of T-cell activation. high fluidity of the membrane, elongated shape, and rugged topography of the surface, all of the properties of endogenous APC, which was found to be a favorable parameter for activation, promote unbiased and efficient CD4 / CD8 T-cell expansion while not severe distinguish cells.

Viral and electroporation-based delivery system gene has many weaknesses. viral vectors are expensive and limited the size of the cargo, while the highly cytotoxic electroporation. Thus, low-cost platform nonviral that transfect T cells with low cytotoxicity and high efficiency required for CAR gene delivery. Our group thus synthesized cationic polymer panels with different architectures and evaluated their abilities T cell transfection.

We identified a comb-shaped polymer formulations were transfected primary T cells with low cytotoxicity, although it was a low transfection efficiency compared to conventional methods. Analysis of intracellular and extracellular barriers to transfection reveal polyplexes low absorption and high endosomal pH in T cells, offensive biological properties and polymers that can further innovation improved.These represent only a few recent developments in the field of biomaterials to address the needs of CAR T cell production. Together, these technologies and their future progress would pave the way for the manufacture of T-cell CAR economical and easy.

CA 15-3, Human Breast Adenocarcinoma

P1435-5 each
EUR 288

9998 SCREW CAP 415/15

9998-15 288/pk
EUR 237.6
Description: General Apparatus; Stoppers

Pesticide Mix 3 Containing 15 Compounds in Acetonitrile

SPXPR-3 1ML
EUR 214.32

Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit

DLR-CA15-3-Hu-48T 48T
EUR 574.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 15-3 (CA15-3) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit

DLR-CA15-3-Hu-96T 96T
EUR 745.2
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 15-3 (CA15-3) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit

RDR-CA15-3-Hu-48Tests 48 Tests
EUR 600

Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit

RDR-CA15-3-Hu-96Tests 96 Tests
EUR 830.4

Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit

RD-CA15-3-Hu-48Tests 48 Tests
EUR 573.6

Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit

RD-CA15-3-Hu-96Tests 96 Tests
EUR 794.4

CA 15-3 protein

30C-CP1064 10 KU
EUR 361.2
Description: Partially purified Human CA 15-3 protein

CA 15-3 protein

30C-CP9064U 10 KU
EUR 684
Description: Highly pure Human CA 15-3 protein

CA 15-3 protein

30-1066 1 kU
EUR 152.4
Description: Purified native Human CA 15-3 protein

CA 15-3 protein

30-AC12 25 KU
EUR 548.4
Description: Partially purified Human CA 15-3 protein

CA 15-3 protein

30-AC16S 25 KU
EUR 613.2
Description: Partially purified Human CA 15-3 protein

CA 15-3 protein

30-AC16S2 25 KU
EUR 807.6
Description: Partially pure native Human CA 15-3 protein

CA 15-3 antibody

10-1144 250 ug
EUR 355.2
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-1145 1 mg
EUR 808.8
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-1146 250 ug
EUR 262.8
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-2344 1 mg
EUR 548.4
Description: Mouse Monoclonal CA 15-3 antibody

CA 15-3 antibody

10-C03E 1 mg
EUR 360
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-C03F 1 mg
EUR 360
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-CA15A 1 mg
EUR 678
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-CA15B 1 mg
EUR 678
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-CA15C 1 mg
EUR 678
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-CA15D 1 mg
EUR 678
Description: Mouse monoclonal CA 15-3 antibody

Anti-Rabbit Whole Serum | GWS-15

GWS-15 1.0 mL
EUR 130
Description:

Anti-Rabbit Whole Serum | GWS-15 | Immunology Consultants Laboratory

Host: Goat

Format: Whole Serum

Product Type: Primary Antibody

Antibody Clonality: Polyclonal

Liquid Wicks, Size 15, 200 /pk

W-15 200 WICKS
EUR 22
Description: Liquid Wicks, Size 15, 200 /pk

Recombinant Human IL-15 Protein

PROTP40933-3 10ug
EUR 380.4
Description: IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowel disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant human IL-15 is a 12.9 kDa protein consisting of 114 amino acid residues.

Swine IL-15 Recombinant Protein

R00212-3 5ug/vial
EUR 310.8
Description: Interleukin-15 (IL-15) is a cytokine with structural similarity to IL-2 that is secreted by mononuclear phagocytes following infection by virus(es). This cytokine induces cell proliferation of natural killer cells. Swine IL-15 Recombinant Protein is purified interleukin-15 produced in yeast.

AXYGEN® HORIZONTAL GEL BOX, 15 CM

HGB-15 1/pk
EUR 583.2
Description: Lab Equipment; Axygen Branded EQ

DiagNano Fluorophore Labeled Gold Nanoparticles, 15 nm

GFL-15 1 mL
EUR 1263.6

Organic Wine Standard 3

WINE-3 1ML
EUR 258.78

AXYGEN® GEL TRAY 15 X 15 CM FOR USE WITH 15 CM GEL BOX, UV TRANSPARENT

HGB15-15-GT 1/pk
EUR 94.8
Description: Lab Equipment; Axygen Branded EQ

DiagNano Gold Nanoparticle Passive Conjugation Kit, 15 nm

GPK-15 1 kit
EUR 858

CA 15-3 ELISA kit

55R-IB19123 96 wells
EUR 528
Description: ELISA kit for the detection of CA 15-3 in the research laboratory

CA 15-3 antibody (HRP)

61-CA15BHRP 500 ul
EUR 418.8
Description: Mouse monoclonal CA 15-3 antibody (HRP)

Gastrointestinal Cancer Antigen (CA 19-9), antigen grade

CA1991-N-10 10 KU
EUR 634.8

Cancer Antigen 15-3 MUC 1 Antigen (Human Milk)

VAng-Cr3871-10kU 10 kU
EUR 505.2
Description: Cancer Antigen 15-3 MUC 1 Antigen, Host/Source: Human Milk. The purity is detected by salt extraction and delipidization following high speed centrifugation. It is tested negative for HBsAg, antibodies to HCV and HIV 1/2.

Paraffin Tissue Section - Human Breast Tumor: Lobular carcinoma

T2235086-3 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Cancer Antigen 15-3 (CA15-3) (human) ELISA Kit

K4804-100 100 assays
EUR 1000.8
Description: Sensitive, Colorimetric Assay

Normal Rabbit Serum | RS-15-100ML

RS-15-100ML 100 mL
EUR 420
Description:

Normal Rabbit Serum | RS-15-100ML | Immunology Consultants Laboratory

Species Reactivity: Rabbit

Format: Serum

Product Type: Isotype Control

Antibody clonality: Polyclonal

Paraffin Tissue Section - Human Brain Tumor: Astrocytoma Grade III

T2235035-3 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Cancer Antigen 15-3 MUC 1 Antigen (Human Ascites Fluid)

VAng-Cr3872-10kU 10 kU
EUR 1363.2
Description: Cancer Antigen 15-3 MUC 1 Antigen, Host/Source: Human Ascites Fluid.

TM-CA 15-3 ELSIA Kit

DEIA2145 96T
EUR 786
Description: The TM-CA 15-3 ELISA is an enzyme immunoassay for measurement of CA15-3 in serum and plasma.

CA 15-3 High Pure Protein

abx061025-10kU 10 kU
EUR 2314.8

RealScreen CA 15-3 ELISA Kit

EL067-096 96T
EUR 1161.6

Breast tumor tissue array (15 of 25)

BR20821 each
EUR 474
Description: Breast tumor tissue array (15 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Sulfur 15 ug/g (15 PPM) for AA and ICP 100 grams in no.2 Diesel Fuel

SDFS-15-Y 100ML
EUR 102.6

Fluorescent Exosome Standard (Urine )

ESF-15 100 µg
EUR 2067.6
Description: Fluorescent exosomes are labeled with green dye, which offer a stable fluorescent labeling.

ICP-MS Calibration Standard 3

CL-CAL-3 125ML
EUR 121.98

DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 15 nm

GCK-M-15 1 kit
EUR 908.4

DiagNano Fluorophore Labeled Gold Nanoparticles, 15 nm, Cellular Uptake

GFL-15-CU 1mL
EUR 1638

ICP-MS Instrument Check Standard 3

CL-ICS-3 125ML
EUR 175.56

Polystyrene Particle Size Standard

PPS-3 mL
EUR 152.4
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Recombinant CA 15-3 Protein (Cell Culture Supernatant)

VAng-Wyb8629-inquire inquire Ask for price
Description: CA 15-3 (Breast Cancer Antigen), Calibrator Grade, recombinant protein from Cell Culture Supernatant, 10003 Units/mL.

TruStrip Sample Transfer Strips, 15-ul, 50/Pk (without sample tracking dye)

STS-15-50 1 Pk Ask for price

TruStrip Sample Transfer Strips, 15-ul, 50/Pk (with sample tracking dye)

STSD-15-50 1 Pk Ask for price

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1032-3 each
EUR 523.2

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1033-3 each
EUR 523.2

Ovarian Cancer Antigen (CA 125)

CA1251-N-10 10 KU
EUR 634.8

Groundwater and Wastewater Pollution Control Check Standard

WP-3 125ML
EUR 112.86

Paraffin Tissue Section - Human Pancreas Tumor: Islet Cell Tumor

T2235188-3 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Cancer Antigen CA-125 Antigen (Human Fluids)

VAng-Wyb8639-inquire inquire Ask for price
Description: CA-125, Calibrator Grade, cancer antigen from Human Fluids, 53.26 KU/mL.

Cancer Antigen CA-125 Antigen (Human Adenocarcinoma)

VAng-Wyb8642-inquire inquire Ask for price
Description: CA-125, Calibrator Grade, Cancer antigen from Human Adenocarcinoma, 500 kIU / mL.

TP62(47&15) Antigen

E62H00703 100ug
EUR 458.4

Human Mucin-1 (MUC-1, CA 15-3) Antibody

32188-05111 150 ug
EUR 313.2

AXYGEN® 10-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-10-15 1/pk
EUR 72
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 12-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-12-15 1/pk
EUR 72
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 20-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-20-15 1/pk
EUR 72
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 35-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-35-15 1/pk
EUR 82.8
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 8-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-8-15 1/pk
EUR 82.8
Description: Lab Equipment; Axygen Branded EQ

T3 (Triiodothyronine) ELISA test

15 96T/Box Ask for price
Description: ELISA based test for quantitative detection of T3 (Triiodothyronine)

Recombinant Transmembrane Protease Serine 2 Protein, Partial

E80016
  • EUR 470.80
  • EUR 753.50
  • EUR 1824.90
  • 20 ul
  • 100 ul
  • 500 ul

Recombinant TMPRSS2 Protein, Partial

E80017
  • EUR 423.50
  • EUR 660.00
  • EUR 2321.00
  • 20 ul
  • 100 ul
  • 1 ml

Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial

E80018
  • EUR 388.30
  • EUR 860.20
  • EUR 4888.40
  • 20 ul
  • 100 ul
  • 1 ml

Cancer Antigen CA 19-9 Antibody

abx023798-1mg 1 mg
EUR 1053.6

Human Cancer PrimaCell4: Breast Tumor Cells

2-96027 1 Kit Ask for price

Mouse Carbohydrate Antigen 15-3(CA15-3)ELISA kit

GA-E0825MS-48T 48T
EUR 403.2

Mouse Carbohydrate Antigen 15-3(CA15-3)ELISA kit

GA-E0825MS-96T 96T
EUR 640.8

Rat CarbohydRate Antigen 15-3(CA15-3)ELISA kit

GA-E0858RT-48T 48T
EUR 424.8

Rat CarbohydRate Antigen 15-3(CA15-3)ELISA kit

GA-E0858RT-96T 96T
EUR 685.2

Rat CarbohydRate Antigen 15-3(CA15-3)ELISA kit

QY-E10794 96T
EUR 433.2

Mouse CarbohydMousee Antigen 15-3(CA15-3)ELISA kit

QY-E20245 96T
EUR 433.2

Canine Carbohydrate Antigen 15-3 (CA15-3)ELISA kit

YLA0015CA-48T 48T
EUR 502.5

Canine Carbohydrate Antigen 15-3 (CA15-3)ELISA kit

YLA0015CA-96T 96T
EUR 618.75

Mouse Carbohydrate Antigen 15-3 (CA15-3)ELISA kit

YLA1079MO-48T 48T
EUR 465

Mouse Carbohydrate Antigen 15-3 (CA15-3)ELISA kit

YLA1079MO-96T 96T
EUR 600

Rat Carbohydrate Antigen 15-3 (CA15-3)ELISA kit

YLA0753RA-48T 48T
EUR 465

Rat Carbohydrate Antigen 15-3 (CA15-3)ELISA kit

YLA0753RA-96T 96T
EUR 600

3-aminobenzamide

79888-3 5 g
EUR 250
Description: 3-aminobenzamide is a novel, potent inhibitor of PARP. Also acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.

AXYGEN® 14-WELL MULTI-CHANNEL COMPATIBLE COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-14MC-15 1/pk
EUR 75.6
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 16-WELL MULTI-CHANNEL COMPATIBLE COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-16MC-15 1/pk
EUR 72
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 18-WELL MULTI-CHANNEL COMPATIBLE COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-18MC-15 1/pk
EUR 72
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 28-WELL MULTI-CHANNEL COMPATIBLE COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-28MC-15 1/pk
EUR 74.4
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 30-WELL MULTI-CHANNEL COMPATIBLE COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-30MC-15 1/pk
EUR 74.4
Description: Lab Equipment; Axygen Branded EQ

MicroMesh: Box of 20 with 80 micron diameter mesh and 15 micron apertures; mounted on 18 mm rods

M3-L18SP-15 20 MOUNTS
EUR 112
Description: MicroMesh: Box of 20 with 80 micron diameter mesh and 15 micron apertures; mounted on 18 mm rods

Paraffin Tissue Section - Human Adrenal Tumor: Myelolipoma

T2235004-3 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Bone Tumor: Chondrosarcoma

T2235023-3 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Testis Tumor: Seminoma

T2235260-3 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Recombinant CA 15-3 Protein (Human BTA Cell Line Supernatant)

VAng-Wyb8630-inquire inquire Ask for price
Description: CA 15-3 (Breast Cancer Antigen), Antigen Grade, recombinant protein from Human BTA Cell Line Supernatant, 20171 Units/mL.

Groundwater and Wastewater Pollution Control Check Standard

WP-15-500N 500ML
EUR 321.48

Breast cancer

BR1008b each
EUR 306
Description: Breast cancer, lymph node metastatic carcinoma and adjacent normal tissue array, including pathology grade, TNM, clinical stage, and ER/PR/Her2 result, 100 cases/100 cores, replacing BR1008a

Breast cancer

BR724 each
EUR 270
Description: Breast cancer, adjacent and adjacent normal tissue array, 66 cases/72 cores

Breast cancer

BR725 each
EUR 270
Description: Breast cancer, adjacent and adjacent normal tissue array, 68 cases/72 cores

Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma (Ulcer)

T2235090-3 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Skin Tumor: Malignant Melanoma

T2235218-3 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Uterus Tumor: Endometrium Adenocarcinoma

T2235274-3 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

15-Methoxyansamitocin P-3

TBZ0596 unit Ask for price

3-Dehydro-15-deoxoeucosterol

TB01583 5mg
EUR 1016.4

Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody

M02431-3 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

IL-3 Interleukin-3 Human Recombinant Protein, His Tag

PROTP08700-3 Regular: 50ug
EUR 380.4
Description: Interleukin-3 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 154 amino acids fragment (20-152) and having a total molecular mass of 17.3kDa and fused with a 20 aa N-terminal His tag. ;The IL3 His is purified by proprietary chromatographic techniques.

Paraffin Tissue Section - Human Gallbladder Tumor: Adenocarcinoma, Well Differentiated

T2235118-3 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Ovary Tumor: Mucous Papillary Cystoadenocarcinoma

T2235183-3 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Stomach Tumor: Adenocarcinoma, Well Differentiated

T2235248-3 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Individual Reaction Mix 3

G065-3 200 reactions
EUR 200.4

3-D Life Thioglycerol

T10-3 180 µl
EUR 57.6

Polyoxyl 15 Hydroxystearate USP, Ph. Eur. grade

GX7347-100G 100 g
EUR 73.2

Polyoxyl 15 Hydroxystearate USP, Ph. Eur. grade

GX7347-1KG 1 kg
EUR 210

Polyoxyl 15 Hydroxystearate USP, Ph. Eur. grade

GX7347-500G 500 g
EUR 132

Cancer Antigen CA-125 Antigen (Human Fluids) (Partially Pure)

VAng-Wyb8637-inquire inquire Ask for price
Description: CA-125 (Ovarian Cancer), Partially Pure, Cancer antigen from Human Fluids, 73.90 kUnits/mL.

Cancer Antigen CA-125 Antigen (Ovarian Carcinoma Cell Line)

VAng-Wyb8641-inquire inquire Ask for price
Description: CA-125, Antigen Grade, Cancer antigen from Ovarian Carcinoma Cell Line, 84,040 Units/mL.

Human Cancer Tissue Preparation Buffer 15: Skin Cancer Cells

9-80038 1 x 100 ml Ask for price

Western Blot Box - 2 7/8 x 1 3/16 x 3/4in.; 7.3 x 3 x 1.9cm

B1200-3 5/pack
EUR 76.52
Description: Western Blot Boxes

TNFR Human, Tumor Necrosis Factor Receptor, sf9 Human Recombinant Protein

PROTQ07011-3 Regular: 10ug
EUR 380.4
Description: TNFR produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 411 amino acids (18-186 a.a.) and having a molecular mass of 45.3kDa. (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant

PROTP10600-3 Regular: 5ug
EUR 380.4
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

3-D-Life SG-PVA

M81-3 3x 170 µl
EUR 177.6

3-D Life FG-PVA

M82-3 3x 170 µl
EUR 177.6

3-D Life SG-Dextran

M91-3 3x 170 µl
EUR 188.4

3-D Life FG-Dextran

M92-3 3x 170 µl
EUR 188.4

3-D Life RGD Peptide

P10-3 3x 1 µmol
EUR 331.2

3-D Life PEG-Link

L50-3 3x 200 µl
EUR 112.8

3-D Life CD-Link

L60-3 3 x 200 µl
EUR 385.2

Dr. P Kit-Solution 3

K2021010-3 50 ml
EUR 159.6
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Recombinant Human MMP-3 Protein

PROTP08254-3 10ug
EUR 380.4
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).

Most of the synthesized compounds exhibited high resistance against cancer cells tested. Additionally, tyrosine kinase and barriers PIM1 done for the most active compounds in which the substituent variation through the aryl ring and heterocyclic rings given compound with high activity. Our analysis shows that there is a strong correlation between the structure of the compound and a substituent of the target molecule.