Biomaterials in Chimeric Antigen Receptor T-Cell Process Development

ConspectusChimeric antigen receptor (CAR) T-cell therapy has changed the landscape of cancer treatments, utilizing modified ex vivo autologous T cells to treat relapsed or refractory B-cell leukemia and lymphoma. However, the impact of wider therapy has been limited, in part, the production process is complicated, lengthy, and expensive. Thus, as a T-cell therapy CAR more developed to treat other cancers, continuous innovation in manufacturing cell will be crucial to their successful clinical implementation.

This account, we describe our research efforts using biomaterials to raise three fundamental steps in T-cell manufacturing CAR: (1) isolation, (2) activation, and (3) genetic modification.Recognizing T cell isolation reagent clinically and supply costs a high obstacle, we developed a synthetic DNA aptamer and complementary reversal agent technology that CD8 + T cells isolated label-free with high purity and yield of mononuclear cells of peripheral blood. Spirit, CAR T cells are made of both antibody and T cell-isolated aptamer comparable in therapeutic potential.

Invention and design of other T-cell specific aptamers and corresponding reversal reagents can fully realize the potential of this approach, enabling inexpensive isolation of different T cell populations in a single insulating step.Current some material ex vivo T-cell activation does not accurately mimic the in situ activation of cells T by antigen presenting cells (APC). They are not the same cause expansion of CD4 + and CD8 + T cells, so it requires a separate production of CD4 + and CD8 + CAR T cells for therapeutic infusion calls for balanced composition.

 Biomaterials in Chimeric Antigen Receptor T-Cell Process Development
Biomaterials in Chimeric Antigen Receptor T-Cell Process Development

To address this shortcoming, we designed a panel of cell-templated silica microparticles with a biodegradable supported lipid bilayers that display ligand stimulation of T-cell activation. high fluidity of the membrane, elongated shape, and rugged topography of the surface, all of the properties of endogenous APC, which was found to be a favorable parameter for activation, promote unbiased and efficient CD4 / CD8 T-cell expansion while not severe distinguish cells.

Viral and electroporation-based delivery system gene has many weaknesses. viral vectors are expensive and limited the size of the cargo, while the highly cytotoxic electroporation. Thus, low-cost platform nonviral that transfect T cells with low cytotoxicity and high efficiency required for CAR gene delivery. Our group thus synthesized cationic polymer panels with different architectures and evaluated their abilities T cell transfection.

We identified a comb-shaped polymer formulations were transfected primary T cells with low cytotoxicity, although it was a low transfection efficiency compared to conventional methods. Analysis of intracellular and extracellular barriers to transfection reveal polyplexes low absorption and high endosomal pH in T cells, offensive biological properties and polymers that can further innovation improved.These represent only a few recent developments in the field of biomaterials to address the needs of CAR T cell production. Together, these technologies and their future progress would pave the way for the manufacture of T-cell CAR economical and easy.

Cancer Antigen CA 15-3 Protein (Human Milk)

VAng-Wyb8631-inquire inquire Ask for price
Description: CA 15-3 (Breast Cancer Antigen), Antigen Grade, Cancer antigen from Human Milk, 33.0 kIU/mL.

CA 15-3, Human Breast Adenocarcinoma

P1435-1
EUR 109

CA 15-3, Human Breast Adenocarcinoma

P1435-5
EUR 240

99445-15 DCT 15 X 85MM

99445-15 250/pk
EUR 97
Description: Disposable Culture Tubes; DCT's, CGW

9998 SCREW CAP 415/15

9998-15 288/pk
EUR 198
Description: General Apparatus; Stoppers

CA 15-3 antibody

10-1144 250 ug
EUR 296
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-1145 1 mg
EUR 674
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-1146 250 ug
EUR 219
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-2344 1 mg
EUR 457
Description: Mouse Monoclonal CA 15-3 antibody

CA 15-3 antibody

10-C03E 1 mg
EUR 300
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-C03F 1 mg
EUR 300
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-CA15A 1 mg
EUR 565
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-CA15B 1 mg
EUR 565
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-CA15C 1 mg
EUR 565
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 antibody

10-CA15D 1 mg
EUR 565
Description: Mouse monoclonal CA 15-3 antibody

CA 15-3 protein

30C-CP1064 10 KU
EUR 301
Description: Partially purified Human CA 15-3 protein

CA 15-3 protein

30C-CP9064U 10 KU
EUR 570
Description: Highly pure Human CA 15-3 protein

CA 15-3 protein

30-1066 1 kU
EUR 127
Description: Purified native Human CA 15-3 protein

CA 15-3 protein

30-AC12 25 KU
EUR 457
Description: Partially purified Human CA 15-3 protein

CA 15-3 protein

30-AC16S 25 KU
EUR 511
Description: Partially purified Human CA 15-3 protein

CA 15-3 protein

30-AC16S2 25 KU
EUR 673
Description: Partially pure native Human CA 15-3 protein

Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit

DLR-CA15-3-Hu-48T 48T
EUR 479
  • Should the Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 15-3 (CA15-3) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit

DLR-CA15-3-Hu-96T 96T
EUR 621
  • Should the Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 15-3 (CA15-3) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit

RD-CA15-3-Hu-48Tests 48 Tests
EUR 478

Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit

RD-CA15-3-Hu-96Tests 96 Tests
EUR 662

Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit

RDR-CA15-3-Hu-48Tests 48 Tests
EUR 500

Human Carbohydrate Antigen 15-3 (CA15-3) ELISA Kit

RDR-CA15-3-Hu-96Tests 96 Tests
EUR 692

Swine IL-15 Recombinant Protein

R00212-3 5ug/vial
EUR 259
Description: Interleukin-15 (IL-15) is a cytokine with structural similarity to IL-2 that is secreted by mononuclear phagocytes following infection by virus(es). This cytokine induces cell proliferation of natural killer cells. Swine IL-15 Recombinant Protein is purified interleukin-15 produced in yeast.

Recombinant Human IL-15 Protein

PROTP40933-3 10ug
EUR 317
Description: IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowel disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant human IL-15 is a 12.9 kDa protein consisting of 114 amino acid residues.

AXYGEN® HORIZONTAL GEL BOX, 15 CM

HGB-15 1/pk
EUR 486
Description: Lab Equipment; Axygen Branded EQ

DiagNano Fluorophore Labeled Gold Nanoparticles, 15 nm

GFL-15 1 mL
EUR 1053

CA 15-3 antibody (HRP)

61-CA15BHRP 500 ul
EUR 349
Description: Mouse monoclonal CA 15-3 antibody (HRP)

CA 15-3 ELISA kit

55R-IB19123 96 wells
EUR 440
Description: ELISA kit for the detection of CA 15-3 in the research laboratory

Gastrointestinal Cancer Antigen (CA 19-9), antigen grade

CA1991-N-10 10 KU
EUR 529

AXYGEN® GEL TRAY 15 X 15 CM FOR USE WITH 15 CM GEL BOX, UV TRANSPARENT

HGB15-15-GT 1/pk
EUR 79
Description: Lab Equipment; Axygen Branded EQ

DiagNano Gold Nanoparticle Passive Conjugation Kit, 15 nm

GPK-15 1 kit
EUR 715

Cancer Antigen 15-3 MUC 1 Antigen (Human Milk)

VAng-Cr3871-10kU 10 kU
EUR 421
Description: Cancer Antigen 15-3 MUC 1 Antigen, Host/Source: Human Milk. The purity is detected by salt extraction and delipidization following high speed centrifugation. It is tested negative for HBsAg, antibodies to HCV and HIV 1/2.

Cancer Antigen 15-3 (CA15-3) (human) ELISA Kit

K4804-100 100 assays
EUR 834
  • Kit components:
  • CA15-3 Ab-coated Microplate (Item A), 96 wells
  • Wash Buffer (20x) (Item B)
  • Human CA15-3 Standard (Item C)
  • Assay Diluent A (Item D)
  • Assay Diluent B (5x) (Item E)
  • Detection Antibody (Item F)
  • HRP-Streptavidin (200x) (Item
  • Show more
Description: Sensitive, Colorimetric Assay

Paraffin Tissue Section - Human Breast Tumor: Lobular carcinoma

T2235086-3 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Brain Tumor: Astrocytoma Grade III

T2235035-3 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Cancer Antigen 15-3 MUC 1 Antigen (Human Ascites Fluid)

VAng-Cr3872-10kU 10 kU
EUR 1136
Description: Cancer Antigen 15-3 MUC 1 Antigen, Host/Source: Human Ascites Fluid.

RealScreen CA 15-3 ELISA Kit

EL067-096 96T
EUR 968

CA 15-3 High Pure Protein

abx061025-10kU 10 kU
EUR 1929
  • Shipped within 5-10 working days.

TM-CA 15-3 ELSIA Kit

DEIA2145 96T
EUR 655
Description: The TM-CA 15-3 ELISA is an enzyme immunoassay for measurement of CA15-3 in serum and plasma.

Fluorescent Exosome Standard (Urine )

ESF-15 100 µg
EUR 1723
Description: Fluorescent exosomes are labeled with green dye, which offer a stable fluorescent labeling.

Polystyrene Particle Size Standard

PPS-3 mL
EUR 127
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

DiagNano Fluorophore Labeled Gold Nanoparticles, 15 nm, Cellular Uptake

GFL-15-CU 1mL
EUR 1365

DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 15 nm

GCK-M-15 1 kit
EUR 757

Recombinant CA 15-3 Protein (Cell Culture Supernatant)

VAng-Wyb8629-inquire inquire Ask for price
Description: CA 15-3 (Breast Cancer Antigen), Calibrator Grade, recombinant protein from Cell Culture Supernatant, 10003 Units/mL.

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1032-3
EUR 436

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1033-3
EUR 436

Ovarian Cancer Antigen (CA 125)

CA1251-N-10 10 KU
EUR 529

TruStrip Sample Transfer Strips, 15-ul, 50/Pk (without sample tracking dye)

STS-15-50 1 Pk Ask for price

TruStrip Sample Transfer Strips, 15-ul, 50/Pk (with sample tracking dye)

STSD-15-50 1 Pk Ask for price

Human Mucin-1 (MUC-1, CA 15-3) Antibody

32188-05111 150 ug
EUR 261

Cancer Antigen CA-125 Antigen (Human Fluids)

VAng-Wyb8639-inquire inquire Ask for price
Description: CA-125, Calibrator Grade, cancer antigen from Human Fluids, 53.26 KU/mL.

Cancer Antigen CA-125 Antigen (Human Adenocarcinoma)

VAng-Wyb8642-inquire inquire Ask for price
Description: CA-125, Calibrator Grade, Cancer antigen from Human Adenocarcinoma, 500 kIU / mL.

Paraffin Tissue Section - Human Pancreas Tumor: Islet Cell Tumor

T2235188-3 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

TP62(47&15) Antigen

E62H00703 100ug
EUR 382

AXYGEN® 10-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-10-15 1/pk
EUR 60
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 12-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-12-15 1/pk
EUR 60
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 20-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-20-15 1/pk
EUR 60
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 35-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-35-15 1/pk
EUR 69
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 8-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-8-15 1/pk
EUR 69
Description: Lab Equipment; Axygen Branded EQ

Mouse Carbohydrate Antigen 15-3(CA15-3)ELISA kit

GA-E0825MS-48T 48T
EUR 336

Mouse Carbohydrate Antigen 15-3(CA15-3)ELISA kit

GA-E0825MS-96T 96T
EUR 534

Rat CarbohydRate Antigen 15-3(CA15-3)ELISA kit

GA-E0858RT-48T 48T
EUR 354

Rat CarbohydRate Antigen 15-3(CA15-3)ELISA kit

GA-E0858RT-96T 96T
EUR 571

Rat CarbohydRate Antigen 15-3(CA15-3)ELISA kit

QY-E10794 96T
EUR 361

Mouse CarbohydMousee Antigen 15-3(CA15-3)ELISA kit

QY-E20245 96T
EUR 361

Cancer Antigen CA 19-9 Antibody

abx023798-1mg 1 mg
EUR 878
  • Shipped within 5-10 working days.

Human Cancer PrimaCell4: Breast Tumor Cells

2-96027 1 Kit Ask for price

Recombinant CA 15-3 Protein (Human BTA Cell Line Supernatant)

VAng-Wyb8630-inquire inquire Ask for price
Description: CA 15-3 (Breast Cancer Antigen), Antigen Grade, recombinant protein from Human BTA Cell Line Supernatant, 20171 Units/mL.

T3 (Triiodothyronine) ELISA test

15 96T/Box Ask for price
  • Area of application: Hormone testing
Description: ELISA based test for quantitative detection of T3 (Triiodothyronine)

BSA (Standard Grade)

30-AB70 1 kg
EUR 899
Description: Standard Grade Bovine Serum Albumin (99% pure)

3-Dehydro-15-deoxoeucosterol

TB01583 5mg
EUR 847

15-Methoxyansamitocin P-3

TBZ0596 unit Ask for price

AXYGEN® 14-WELL MULTI-CHANNEL COMPATIBLE COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-14MC-15 1/pk
EUR 63
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 16-WELL MULTI-CHANNEL COMPATIBLE COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-16MC-15 1/pk
EUR 60
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 18-WELL MULTI-CHANNEL COMPATIBLE COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-18MC-15 1/pk
EUR 60
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 28-WELL MULTI-CHANNEL COMPATIBLE COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-28MC-15 1/pk
EUR 62
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 30-WELL MULTI-CHANNEL COMPATIBLE COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-30MC-15 1/pk
EUR 62
Description: Lab Equipment; Axygen Branded EQ

IL-3 Interleukin-3 Human Recombinant Protein, His Tag

PROTP08700-3 Regular: 50ug
EUR 317
Description: Interleukin-3 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 154 amino acids fragment (20-152) and having a total molecular mass of 17.3kDa and fused with a 20 aa N-terminal His tag. ;The IL3 His is purified by proprietary chromatographic techniques.

Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody

M02431-3 100ug/vial
EUR 397
Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

Paraffin Tissue Section - Human Adrenal Tumor: Myelolipoma

T2235004-3 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Bone Tumor: Chondrosarcoma

T2235023-3 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Testis Tumor: Seminoma

T2235260-3 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Polyoxyl 15 Hydroxystearate USP, Ph. Eur. grade

GX7347-100G 100 g
EUR 61

Polyoxyl 15 Hydroxystearate USP, Ph. Eur. grade

GX7347-1KG 1 kg
EUR 175

Polyoxyl 15 Hydroxystearate USP, Ph. Eur. grade

GX7347-500G 500 g
EUR 110

Individual Reaction Mix 3

G065-3 200 reactions
EUR 167

3-D Life Thioglycerol

T10-3 180 µl
EUR 48

Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma (Ulcer)

T2235090-3 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Skin Tumor: Malignant Melanoma

T2235218-3 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Uterus Tumor: Endometrium Adenocarcinoma

T2235274-3 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Western Blot Box - 2 7/8 x 1 3/16 x 3/4in.; 7.3 x 3 x 1.9cm

B1200-3 5/pack
EUR 63.77
Description: Western Blot Boxes

Human Cancer Tissue Preparation Buffer 15: Skin Cancer Cells

9-80038 1 x 100 ml Ask for price

Human Mucin-1 (MUC-1, CA 15-3) Antibody (Biotin Conjugate)

32188-05121 150 ug
EUR 369

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant

PROTP10600-3 Regular: 5ug
EUR 317
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

Cancer Antigen CA-125 Antigen (Human Fluids) (Partially Pure)

VAng-Wyb8637-inquire inquire Ask for price
Description: CA-125 (Ovarian Cancer), Partially Pure, Cancer antigen from Human Fluids, 73.90 kUnits/mL.

Cancer Antigen CA-125 Antigen (Ovarian Carcinoma Cell Line)

VAng-Wyb8641-inquire inquire Ask for price
Description: CA-125, Antigen Grade, Cancer antigen from Ovarian Carcinoma Cell Line, 84,040 Units/mL.

Paraffin Tissue Section - Human Gallbladder Tumor: Adenocarcinoma, Well Differentiated

T2235118-3 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Ovary Tumor: Mucous Papillary Cystoadenocarcinoma

T2235183-3 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Stomach Tumor: Adenocarcinoma, Well Differentiated

T2235248-3 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Dr. P Kit-Solution 3

K2021010-3 50 ml
EUR 133
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

3-D Life RGD Peptide

P10-3 3x 1 µmol
EUR 276

Recombinant Human MMP-3 Protein

PROTP08254-3 10ug
EUR 317
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).

3-D-Life SG-PVA

M81-3 3x 170 µl
EUR 148

3-D Life FG-PVA

M82-3 3x 170 µl
EUR 148

3-D Life SG-Dextran

M91-3 3x 170 µl
EUR 157

3-D Life FG-Dextran

M92-3 3x 170 µl
EUR 157

3-D Life PEG-Link

L50-3 3x 200 µl
EUR 94

3-D Life CD-Link

L60-3 3 x 200 µl
EUR 321

pLenti-CARM1 shRNA-3 Plasmid

PVTBAV03691-3 2 ug
EUR 356

pLenti-CTLA4 shRNA-3 Plasmid

PVTBAV05689-3 2 ug
EUR 356

pLenti-FOXM1 shRNA-3 Plasmid

PVTBAV08732-3 2 ug
EUR 356

pLenti-JUN shRNA-3 Plasmid

PVTBAV11741-3 2 ug
EUR 356

pLenti-LHX6 shRNA-3 Plasmid

PVTBAV12881-3 2 ug
EUR 356

pLenti-MAGEA3 shRNA-3 Plasmid

PVTBAV13661-3 2 ug
EUR 356

pLenti-RUNX3 shRNA-3 Plasmid

PVTBAV20583-3 2 ug
EUR 356

pLenti-Slc7a11 shRNA-3 Plasmid

PVTBAV21973-3 2 ug
EUR 356

pLenti-STAT3 shRNA-3 Plasmid

PVTBAV22921-3 2 ug
EUR 356

Recombinant (E. coli) Dengue Virus Type 3 E Antigen (DENV-E), antigen grade (>95%, 15 kda, no tag)

RP-1596 50 ug
EUR 408

Breast Cancer-Associated Antigen BRCAA1 (BRCAA1) Antibody

20-abx148333
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Inactivated CMV Grade 3 Antigen

VAng-Lsx0038-1mg 1 mg
EUR 2086
Description: CMV Grade 3, natural protein.

Inactivated MuV Grade 3 Antigen

VAng-Lsx0411-inquire inquire Ask for price
Description: MuV grade 3, native protein.

Inactivated Rotavirus Grade 3 Antigen

VAng-Lsx0469-inquire inquire Ask for price
Description: Rotavirus Grade 3, native virus.

Inactivated RuV Grade 3 Antigen

VAng-Lsx0476-1mL 1 mL
EUR 395
Description: RuV Grade 3, natural protein.

TNFR Human, Tumor Necrosis Factor Receptor, sf9 Human Recombinant Protein

PROTQ07011-3 Regular: 10ug
EUR 317
Description: TNFR produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 411 amino acids (18-186 a.a.) and having a molecular mass of 45.3kDa. (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).

FSH (Human Follicle-stimulating hormone) ELISA test

3 96T/Box Ask for price
  • Area of application: Hormone testing
Description: ELISA based test for quantitative detection of FSH (Human Follicle-stimulating hormone)

Anti-VEGF Receptor 3/FLT4 Antibody

A01276-3 100ug/vial
EUR 334

Caspase-3 Inhibitor Q-DEVD-OPh

1175-3
EUR 533

3-D Life Scrambled RGD Peptide

P11-3 3x 1 µmol
EUR 276

GCDFP-15 (Gross Cystic Disease Fluid Protein 15) (Breast Marker) (PIP/1571) Antibody

BNC551571-100 100uL
EUR 199
Description: Primary antibody against GCDFP-15 (Gross Cystic Disease Fluid Protein 15) (Breast Marker) (PIP/1571),CF555 conjugate, Concentration: 0.1mg/mL

Most of the synthesized compounds exhibited high resistance against cancer cells tested. Additionally, tyrosine kinase and barriers PIM1 done for the most active compounds in which the substituent variation through the aryl ring and heterocyclic rings given compound with high activity. Our analysis shows that there is a strong correlation between the structure of the compound and a substituent of the target molecule.